KERIC - Karolinska Experimental Research and Imaging Centre

KERIC - Karolinska Experimental Research and Imaging Centre

KERIC offering different imaging analyses in experimental systems in combination with experimental surgery in large animals like swine as well as in rodents. The unit belongs to the department of comparative medicine (AKM) and is situated at Karolinska University Hospital, Solna. We provide tools for angiography, MRI, microPET and a combined nano PET-MRI /CT, and offer our resources to both academic research, training courses and for external clients to develop and test new equipment.

 

Angiography

The Dept of Neuroradiology manages the angiography unit, coordinates reservations and provides assistance by a dedicated radiology nurse (technician).

 

  • Research in endovascular devices
  • Experimental stroke research, combined with MRI and microPET
  • Radiation reduction in angiography
  • Development of direct puncture devices
  • Superselective stem cell installation
  • Courses in endovascular stroke treatment

 µPET

  The microPET Focus 120 (Siemens, CTI) is a stand-alone rodent camera for performing dynamic (every second for minutes up to hours) studies of molecules labeled with positron-emitting nuclides. It has a high sensitivity, resolution of 1.3 mm, axial field-of-view 7.6 - 22 cm (CBM) and a removable bed for repositioning in other imaging modalities. It is used in (but not limited to) evaluations of:

  • Novel imaging molecules, from small molecules to proteins
  • Longitudinal studies of normo- and pathophysiology
  • New biomarkers of disease processes
  • Novel administration routes
  • Efficacy of experimental vs. conventional therapies

Complementary in vitro and ex vivo pharmacological techniques, cryosectioning and phosphoimaging are also available.

nanoScan PET-MRI/CT

The unit is equipped with a state-of-the-art Mediso nanoScan® PET-MRI/CT multimodal small animal imaging system, comprising a 1T static MRI modul (spatial resolution < 100 µm), a PET modul (spatial resolution 0.8mm) and a CT modul (voxel size: 10-34 µm). The unit can offer multimodal (PET, CT, MRI) quantitative imaging measurements on small animals for studies related to for example:

  • Radioligand development
  • Molecular imaging biomarker development
  • Drug development (microdosing, occupancy, etc.)
  • Various molecular imaging experiments in translational animal models

MRI

 

The MRI platform has a 9.4 T Varian scanner with a 30 cm bore. It is a well equipped state-of-the-art system, which is ideal for characterizing different rat and mouse models for various diseases and translational research. We can offer support to research groups from academia and industry with different applications such as:

  • Anatomical imaging of brain and whole body (2 and 3-D)
  • Functional imaging (fMRI, pharmacological MRI and cardiac imaging)
  • Magnetic Resonance Spectroscopy (1H MRS)

 

Large Animal Surgery

The surgery facility consists of four full size operation units for large animals equipped with ventilators and monitors for physiological functions and in addition harbour a robotic platform (a da Vinci system) that offer training in minimally invasive surgery. The facility is well suited for courses, clinical training and research projects. Moreover KERIC includes two laboratories for small animal (mouse and rat) surgery. Rodents are stored in individual ventilated cages (IVC) in a designed room to minimize risk of contamination. 

Practical information

For further information, order forms and price list please contact:

Operations manager Anki Nordqvist
Phone: +46 (0)70 167 10 72
 

Interested in Industry collaboration
Karolinska University Hospital
Stockholm
+46 (0)8 517 765 26