Peptide synthesis and cell-penetrating peptides

Peptide synthesis and cell-penetrating peptides

At the Department of Neurochemistry we have developed a solid-phase methodology to synthesize peptides, with the purpose to study different processes in disease. Furthermore, we study cell-penetrating peptides that function as cellular transporters through biological membranes, with the purpose to develop a system for delivering drugs across the blood barrier.

Description

The research projects at the department are primarily aimed to describe and characterize, in molecular terms, interaction and signalling in sensory and cognitive processes and in more long term, processes such as synaptogenesis, neuronal plasticity and degeneration. Many different approaches are applied and successfully combined in the studies; from organic and peptide synthesis to molecular and cell biology.

Among our many projects, we have developed a solid-phase methodology to synthesise peptides. Another main project concerns the cell-penetrating peptides that function as cellular transporters through biological membranes.

Infrastructure/Methods

Synthesis of peptides

With the aim to study the pharmacological effects of certain synthetic peptides we have established a solid-phase method to create synthetic peptides. These may be used in many different studies, like the understanding of disease.

Cell-penetrating peptides

Cell-penetrating peptides, CPP, are able to function as cellular transporters through biological membranes. As these CPP:s or transportans, can carry another agent, e.g a protein, they offer additional methods for research and therapeutic use. Currently, our interest is also concerned with the possibility to deliver drugs across blood brain barrier. Cellular delivery of peptides, short oligonucleotides such as siRNA, peptide nucleic acid oligomers, proteins and even plasmids for transfection has been achieved. More information is available on our website.

Practical information

We are especially interested in collaboration projects where we can contribute with our specific expertise in e.g. cell-penetrating peptides and peptide synthesis. We are also interested in joint applications for funding of equipment or projects. Please see more information on our research projects and expertise on our website.

Interested in Industry collaboration
Frescati Backe, Svante Arrheniusv väg 21 A
Stockholm University
106 91 Stockholm
+46 (0)8 16 42 68